doi: 10.4161/cc.9īarisic M, Sohm B, Mikolcevic P et al (2010) Spindly/CCDC99 is required for efficient chromosome congression and mitotic checkpoint regulation. doi: 10.1098/rsta.2013.0392īarisic M, Geley S (2011) Spindly switch controls anaphase: spindly and RZZ functions in chromosome attachment and mitotic checkpoint control. Philos Trans A Math Phys Eng Sci 373:20130392. Trends Biochem Sci 23:284–286īarford D (2015) Understanding the structural basis for controlling chromosome division. doi: 10.1038/ncb3179Īravind L, Koonin EV (1998) The HORMA domain: a common structural denominator in mitotic checkpoints, chromosome synapsis and DNA repair. doi: 10.1038/nature19083Īravamudhan P, Goldfarb AA, Joglekar AP (2015) The kinetochore encodes a mechanical switch to disrupt spindle assembly checkpoint signalling. This process is experimental and the keywords may be updated as the learning algorithm improves.Īlfieri C, Chang L, Zhang Z et al (2016) Molecular basis of APC/C regulation by the spindle assembly checkpoint. These keywords were added by machine and not by the authors. Anaphase-Promoting Complex/Cyclosome (APC/C).This chapter seeks to synthesize these recent advances and place them in a biological context, in order to explain the mechanisms of SAC activation and silencing at a molecular level. In the past few years, advances in biochemical reconstitution, structural biology, and bioinformatics have fueled an explosion in the molecular understanding of the SAC. While the identities of SAC components have been known, in some cases, for over two decades, the molecular mechanisms of the SAC have remained mostly mysterious until very recently. In eukaryotic cell division, the Spindle Assembly Checkpoint (SAC) plays a key regulatory role by monitoring the status of chromosome-microtubule attachments and allowing chromosome segregation only after all chromosomes are properly attached to spindle microtubules.

Spindle assembly checkpoint